There are many places that one comma will not do as there is not a need to separate anything. In these places, IF there is a need for punctuate, it is a choice of two commas or no commas.
...He has specifically changed the wording for the brochure...
There is no place for one comma. Do we need two commas with "specifically" or no commas?
...Has she at any time mentioned his drug use?
There is no place for one comma. Do we need two commas with "at any time" or no commas?
...He has, however, changed the wording for the brochure...
There is no place for one comma. Do we need two commas with "however" or no commas?
...Has she, by the way, mentioned his drug use?
There is no place for one comma. Do we need two commas with "by the way" or no commas?
Happy punctuating!
Margie